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What is CADASIL?

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a rare genetic disease affecting the small blood vessels of the brain.  It leads to a poor irrigation of certain areas of the brain which causes symptoms that vary from person to person.   CADASIL affects just as many men as women.

This disease is caused by an anomaly (mutation) of one single gene, called Notch3, found on chromosome 19. This gene plays a part in the formation of the blood vessels and the way they work.  It's mutation has an impact on the movement of blood inside the brain. 
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ICD-10-CM I67.850 is a new dignosis code for CADASIL that became effective on October 1, 2018.

About Us


http://cadasilfoundation.org/picts/1%20arrow-small%20-.gifHow Others Cope
These are families who has shared their experiences with how they deal with CADASIL.

http://cadasilfoundation.org/picts/1%20arrow-small%20-.gifSupport Group Forum
This forum was established in 1997. This support forum is for patients, spouses, parents, families and friends all bound together by the common experience of CADASIL.

http://cadasilfoundation.org/picts/1%20arrow-small%20-.gifCADASIL Caregivers
Since CADASIL has so many different symptoms, it is impossible to find a caregivers group just for CADASIL.

Caregivers are encouraged to look in your community for support groups for the symptoms your love one is having. 


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Who we are

Until CADASIL Together We Have Hope was established in 2005, there was nowhere to turn for assistance and support. 

Please take your time to browse through the website.  We have compiled a wealth of information and resources through our carefully nurtured relationships and collaboration with a plethora of medical professionals, researchers, and organizations throughout the world.  Feel free to download any of the information from the website and forward it on to family members, friends, and especially medical professionals. If you have difficulty finding the information you need, please call us at 512-608-1611 or e-mail us at info@cadasilfoundation.org


CADASIL Together We Have Hope Non-Profit was established on May 10, 2005 as a non-profit organization. We pledge to continue our efforts to increase awareness, education, and knowledge of this disease with up-to-date information from trustworthy and reliable resources. We require no membership as we are here for you!

We are devoted to promoting advocacy, awareness, education, research and support. We are dedicated to enhancing the established communication network among families as well as identifying sources of medical care and social services.  We foster advocacy and open communication among all stakeholders as we work collaboratively to find a treatment or cure for CADASIL. Find out more 

The non-profit has established affiliations with various CADASIL (and other rare disease) organizations, doctors, and researchers in addition to expanding collaborative efforts with new partners... More... We are honored to be affiliated with . .


We are a 501(c)(3) non-profit organization, recognized by the IRS as eligible to receive tax-deductible donations.  We would not exist without your support and are here for you.  No matter what the size of your donation, you will impact the lives of many.  Remember we have no paid staff and do not require membership dues.  We run solely on donations and volunteers. Since 2018 we have donated over 36,650.00 directly to research.

Click here for donation form, if you wish to donate in honor or remember a person or make a donation by mail.


Raise funds for CADASIL when you use amazon.com

* Amazon will donate 0.5% of the price of your eligible AmazonSmile purchases to CADASIL Together We Have Hope Non-Profit Organization whenever you shop on AmazonSmile. AmazonSmle is the same Amazon you know.


.Visit our sister site CADASIL French Association - d Cervco Center, Paris, France
2 University of Cambridge UK, dlF3 German Center, 2 Italian Group,d Glasgow, Scotland,  UK Trust Dedication, England


The information provided on this website is designed to complement, not replace the relationship between a patient and his/her own physician.



updated 07/30/2021