CADASIL Together We Have Hope Non-Profit Organization

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a rare genetic disease affecting the small blood vessels of the brain.  It leads to a poor irrigation of certain areas of the brain which causes symptoms that vary from person to person.    CADASIL affects just as many men as women.

This disease is caused by an anomaly (mutation) of one single gene, called Notch3, found on chromosome 19. This gene plays a part in the formation of the blood vessels and the way they work.  It's mutation has an impact on the movement of blood inside the brain.  CADASIL is caused by a mutation (a defect) in Notch 3, gene located on the chromosome 19. Read more

Professor Hugues Chabriat, the Head of the Department of Neurology in University Hospital Lariboisiere and Coordinator of the Referral Centre for Rare Cerebrovascular Diseases ( in Paris, France.

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CADASIL Together We Have Hope Non-Profit was established on May 10, 2005 as a non-profit organization. The organization has followed the Health On the Net (HON) guidelines, which promotes and guides the deployment of useful and reliable online health information and its appropriate and efficient use. We pledge to continue our efforts to increase awareness, education, and knowledge of this disease with up-to-date information from trustworthy and reliable resources. We require no membership as we are here for you!

We are devoted to promoting advocacy, awareness, education, research and support. We are dedicated to enhancing the established communication network among families as well as identifying sources of medical care and social services.  We foster advocacy and open communication among all stakeholders as we work collaboratively to find a treatment or cure for CADASIL. More...Find out more

The non-profit has established affiliations with various CADASIL (and other rare disease) organizations, doctors, and researchers in addition to expanding collaborative efforts with new partners... More... We are honored to be affiliated with . . .

We are a 501(c)(3) non-profit organization, recognized by the IRS as eligible to receive tax-deductible donations.  We would not exist without your support and are here for you.  No matter what the size of your donation, you will impact the lives of many.  Remember we have no paid staff and do not require membership dues.  We run solely on donations and volunteers. More...Donate Volunteer

Until CADASIL Together We Have Hope was established in 2005, there was nowhere to turn for assistance and support. 

Please take your time to browse through the website.  We have compiled a wealth of information and resources through our carefully nurtured relationships and collaboration with a plethora of medical professionals, researchers, and organizations throughout the world.  Feel free to download any of the information from the website and forward it on to family members, friends, and especially medical professionals. If you have difficulty finding the information let us know.



The information provided on this website is designed to complement, not replace the relationship between a patient and his/her own physician.

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