CADASIL - Questions and Answers Official Site

Questions and Answers

This section was created so you can view questions and answers to some common queries about CADASIL.

If you cannot locate your answer, please contact us so we can present your question on to our Scientific Advisory Committee.

Current Questions:

Does hemplegic migraines have anything to do with CADASIL?

Familial hemiplegic migraine is not related to CADASIL, it is not a vascular disorder and it is caused by mutations of other genes. However, CADASIL is increasing the risk of migraine with aura (40% have migraine with aura) and hemiplegic migraine can be observed in CADASIL patients as other types of migraine with aura. (2016)

If a patient had a skin biopsy and it was positive but the blood test was negative, what should the patient do? The first step is to check the results of skin biopsy and to ensure that granular osmiophilic material is present. If this is the case, searching all mutations using a complete screening of the NOTCH3 gene is needed. (2016)

Click on the subject your are interested in or you may scroll down:

Prevention	Headaches/Migraines	Dental
Medicines/Procedures	Disease Relationships	Flying
Are these Symptoms?	Mutations/Genes	Donating Blood
Tests	Medical Terminology	Donating Bone Marrow
Course of the Disease	Strokes/TIA's	Dementia
History of the Disease	Research/Studies	Pregnancy
		Genes
The information provided on this website is designed to complement, not replace the relationship between a patient and his/her own physician.

Course of the Disease

What are the main clinical manifestations of CADASIL?

In CADASIL, is there a difference between men and women with the progress of the disease?

What is the current life span to be expected?

What can the course of the disease, knowing that each patient's disease presents itself in different ways?

What should I do for long term care for my spouse?

Genetic testing in the case of a mutation in the Notch# (exon 4) what is the indication that triggers progression to a serious phase?

Prevention

Is there diet, environment activity changes to be made?

Does stress have any impact on CADASIL?

What should I do for long term care for my spouse?

I have three children, understand that there is a 50% of inheriting the gene, should they be tested? If so, when?

"What attitude should we adopt with young people who intend to become parents when there is the risk that they are suffering from CADASIL and transmitting the disease?"

Medicines/Procedures

Are there any complications with Anesthesia?
Is there any medicines, procedures, I should avoid?
What relief is any is available?

Does Hyperbaric Oxygen Therapy help?
Would recombinant tissue plasminogen activator (rtPA) work for patients?
Does the treatment NeuroAiD, derived from Chinese medicine, can be effective to recover after a stroke? Can be prescribed by a neurologist or is it only sold online? It seems expensive?
In 2008 you said, regarding statins," it is desirable, based on current level of knowledge, to consider statins only in the presence of exceedingly high cholesterol.". What is your opinion about them now (in 2012) and why?

Are these Symptoms?

In my family, people with CADASIL have a very particular way of walking, at an advanced stage of the disease: small steps, dragging their feet, leaning forward or sideways is this characteristic of the disease?

Stress, worries, frustrations etc, are they aggravating factors of the disease?

Could CADASIL show up in these areas earlier in life and misdiagnosed as something else just as it is in the brain?

What type of mood disturbances is usual?

Does the disease or the consequences of stroke, can cause urinary problems? .

Can CADASIL cause lower back problems?

Do patients develop all of the symptoms especially stroke and dementia. Not necessarily. It depends on how long you live.

Tests

What tests are done for CADASIL?

Can an MRI confirm a diagnosis of CADASIL?

Can a spinal tap diagnose CADASIL?

Research and or Studies

What studies or clinical trials are there?

Potential therapeutic avenues?

What is the current status of the research?

Will you use the virtual brain for therapeutic trials?

Has the research path about the impact on how Statin drug improves the health of CADASIL patients been explored? Can you confirm?

What is the mechanism?

Strokes/TIA's

What is the difference between a TIA and a mini stroke?

If you have had almost 40 TIA’s in the last years, will stroke follow?

What should my wife look for in the event of a stroke?

Does the disease or the consequences of stroke, can cause urinary problems?

Why not smooth muscle tissue in the intestinal/bowel areas, lungs or esophagus?

Headaches/Migraines

In CADASIL, which gender has migraine with aura first, or is there a difference?

In case of a migraine, what can be assumed and how to know it’s just a headache?When headaches stop, does that mean

CADASIL stops or slows down in progressions?

Is there a difference between CADASIL and FHM – Familial Hemiplegic Migraine?

Any Relationship with other diseases

I have had 12 MRI’s and a CT in the last 3 years, nothing was ever discovered except two old bleeds and a Cavernous
Angioma with Blooming (6mm), is it related?

If a patient was diagnosed with MS, treated with drugs for MS then finds out they have CADASIL. What is the risk of the MS drugs being dangerous to them with CADASIL?

Is there any coalition between Fibromyalgia and CADASIL?

Can CADASIL cause my Cialis to stop working?

Could CADASIL show up in these areas earlier in life and misdiagnosed as something else just as it is in the brain?

Do any CADASIL sufferers have concurrent problems like ulcer, apparent Crohn's disease, unexplained asthma?

Why is it believed that CADASIL affects only smooth muscle tissues in the circulatory system?

Is it that there may be a link between these three diseases: CADASIL, lower limb arteritis and ankylosing spondylitis according to the information because we had the gene mutated Notch3 is the cause of the fragility of the arteries?

My grandmother died of MS and 3 aunts had dementia and advance stage Alzheimer, is there a correlation?

Mutations/Genes

The Lab results show my mutation has never been seen before, what does this mean?

Is that possible that CADASIL patients may come from the same original family?

Among patients with CADASIL, how many genes are counted

What is de novó CADASIL?

Medical Terminology

What is de novó CADASIL?

What does PADAMAL mean?

Pregnancy

Is there you have any advice on care during the pregnancy if you have CADASIL?

Dental

My dentist is about to pull a tooth and wants me to replace Plavix for a certain period before and after surgery. What do you think?

Flying

Flying is it the cause of neurological disorders?

Donating Blood

Can a patient donate blood?

Donating Bone Marrow

Donating bone marrow is it possible if you are suffering from CADASIL?

Dementia in CADASIL is the effect of what part of the brain?

Can CADASIL patients present dementia without having any history of stroke and without any focal symptoms?

Contact us if you can't find the answer to your question!

The information provided on this website is designed to complement, not replace the relationship between a patient and his/her own physician.

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