"I have hearing loss problems that have been getting worse in the last two years. Is there a cause-and-effect relationship with CADASIL? "

Are there similarities between Parkinson's disease, Lewy body disease and CADASIL?

Are anesthesia, MRI, or certain medications not recommended or even prohibited? What do you think of statins (cholesterol drugs)?

A researcher has demonstrated that blood factor is very effective in increasing vascularization of the brain?

"Could the feeling of pain be measured in the patient? In particular, how can we assess pain by a patient who can no longer speak? "

"Urinary incontinence?"

With CADASIL, is a cerebral vessel dilated and at the same time limited in its capacity to dilate? 

Will Stem Cell help people with CADASIL?

Should I give up smoking, if I have CADASIL?

• Are there any complications with Anesthesia?
  Is there any medicines, procedures, I should avoid?
  What relief is any is available? 
  
  Does Hyperbaric Oxygen Therapy help? 
  Would recombinant tissue plasminogen activator (rtPA) work for patients?
  Does the treatment NeuroAiD, derived from Chinese medicine, can be effective to recover after a stroke? Can be prescribed by a neurologist or is it only sold online? It seems expensive?
  In 2008 you said, regarding statins," it is desirable, based on current level of knowledge, to consider statins only in the presence of exceedingly high cholesterol.". What is your opinion about them now (in 2012) and why?
  "What is cognitive rehabilitation? Would it work in the recovery in the aftermath of a stroke or delay some symptoms? Who is prescribing and practicing it?

Are these Symptoms?

In my family, people with CADASIL have a very particular way of walking, at an advanced stage of the disease: small steps, dragging their feet, leaning forward or sideways is this characteristic of the disease?
Stress, worries, frustrations etc, are they aggravating factors of the disease? 
Could CADASIL show up in these areas earlier in life and misdiagnosed as something else just as it is in the brain? 
What type of mood disturbances is usual?
Does the disease or the consequences of stroke, can cause urinary problems? . 

Can CADASIL cause lower back problems?

Do patients develop all of the symptoms especially stroke and dementia. Not necessarily. It depends on how long you live.
"A young woman in my family who is 35 years old carries the CADASIL gene. She suffered two optic neuritis. It is said to her that this is not related to the disease. But it is not reassuring for her. What is your opinion?"

Tests

What tests are done for CADASIL?
Can an MRI confirm a diagnosis of CADASIL?
Can a spinal tap diagnose CADASIL?
If a patient had a skin biopsy and it was positive but the blood test was negative, what should the patient do?

Research and or Studies

What studies or clinical trials are there?
Potential therapeutic avenues?
What is the current status of the research?
Will you use the virtual brain for therapeutic trials?
Has the research path about the impact on how Statin drug improves the health of CADASIL patients been explored? Can you confirm?
 What is the mechanism? 
"Dr. Joutel talks about future medical trials. This hope of reaching a cure one day (and everyone is anxious for it) is what supports us. We have difficulties in imagining different stages to obtain the approval for a drug (or treatment). We hear about evaluation phases 1, 2, 3, etc. Could you tell us where we are today and what steps have already been accomplished? What steps are left to go? What are their potential durations? Can we have an idea of the process costs and how we can hope enough funding will be found? 

Strokes/TIA's

What is the difference between a TIA and a mini stroke?

If you have had almost 40 TIA’s in the last years, will stroke follow? 

What should my wife look for in the event of a stroke?

Does the disease or the consequences of stroke, can cause urinary problems? 
Why not smooth muscle tissue in the intestinal/bowel areas, lungs or esophagus?


Headaches/Migraines

In CADASIL, which gender has migraine with aura first, or is there a difference?
In case of a migraine, what can be assumed and how to know it’s just a headache?When headaches stop, does that mean
CADASIL stops or slows down in progressions?

Is there a difference between CADASIL and FHM – Familial Hemiplegic Migraine?
Does hemplegic migraines have anything to do with CADASIL?

Any Relationship with other diseases

I have had 12 MRI’s and a CT in the last 3 years, nothing was ever discovered except two old bleeds and a Cavernous 
Angioma with Blooming (6mm), is it related? 

If a patient was diagnosed with MS, treated with drugs for MS then finds out they have CADASIL.  What is the risk of the MS drugs being dangerous to them with CADASIL?

Is there any coalition between Fibromyalgia and CADASIL?

Can CADASIL cause my Cialis to stop working?
Could CADASIL show up in these areas earlier in life and misdiagnosed as something else just as it is in the brain? 
Do any CADASIL sufferers have concurrent problems like ulcer, apparent Crohn's disease, unexplained asthma?
Why is it believed that CADASIL affects only smooth muscle tissues in the circulatory system?
Is it that there may be a link between these three diseases: CADASIL, lower limb arteritis and ankylosing spondylitis according to the information because we had the gene mutated Notch3 is the cause of the fragility of the arteries?

My grandmother died of MS and 3 aunts had dementia and advance stage Alzheimer, is there a correlation?



Mutations/Genes



The Lab results show my mutation has never been seen before, what does this mean?

Is that possible that CADASIL patients may come from the same original family? 
 Among patients with CADASIL, how many genes are counted

What is de novó CADASIL?



Medical Terminology



What is de novó CADASIL?

What does PADAMAL mean?

Pregnancy

Is there you have any advice on care during the pregnancy if you have CADASIL?



Dental 



My dentist is about to pull a tooth and wants me to replace Plavix for a certain period before and after surgery. What do you think?



Flying 



Flying is it the cause of neurological disorders?

Donating Blood 

Can a patient donate blood?

Donating Bone Marrow

Donating bone marrow is it possible if you are suffering from CADASIL?

Dementia

Dementia in CADASIL is the effect of what part of the brain? 
Can CADASIL patients present dementia without having any history of stroke and without any focal symptoms?